FlowCam Products

The FlowCam 8000 combines digital imaging, flow cytometry, and microscopy into a single instrument. Count and analyze tens of thousands of particles per minute and see your sub-visible particles with superior image quality.

• Particle sizing and imaging 2 µm to 1 mm with magnification options of 20x, 10x, 4x and 2x
• Minimum sample volume of 100 µL
• Sample processing capability from 0.05 mL/minute up to 10 mL/minute, depending on flow cell configuration.
• High-resolution camera available in color or monochrome
• Maximum particle concentration of 5 million particles/mL at 2.5 µm particle size
• Compatible with ALH for FLowCam automated liquid handler
• Fluorescence excitation options (488 nm, 532 nm, 633 nm) with 2-channel fluorescence detection

Innovative particle characterization with FlowCam LO combines flow imaging microscopy (FIM) and light obscuration (LO) into a single analytical solution.  

Beyond the compendial light obscuration method to fulfill USP <787> and <788> requirements, flow imaging microscopy provides an orthogonal method for quality control of subvisible particulate matter.

• Perform both flow imaging and light obscuration measurements sequentially in the same instrument
• Obtain compenidal particle sizing and counting according to USP <787> and <788>
• Acquire statistically significant results in less than a minute, with as little and 100 µL of sample
• Monitor and control particulates in your formulations
• Particle size range: 200 µm to 70 µm; Flow imaging module: 10x (~ 100x magnification)
• Minimum sample volume: 100 µL
• Sample flow rate: 0.2 mL/minute

FlowCam Nano provides dynamic image analysis of submicron particle from 300 nm to 2 µm, bridging the gap between traditional flow imaging microscopy and other particle analysis techniques.

Use FlowCam Nano for early detection of aggregates and contaminant monitoring for protein formulations, nano-drug delivery systems, characterization of bacteria, bioprocess monitoring and materials characterizatrion.

• Detect early API aggregate formation and other forms of sample degradation that are prone to generating larger subvisible and visible particles
• Acquire high-resolution images to detect and identify submicron particle types to inform product development and monitor product quality
• Obtain size, morphology, and relative concentrations of particles that are too small to be detected by traditional Flow Imaging Microscopy
• Flow imaging and particle sizing from 300 nm to 2 µm using oil immersion with 40X magnification
• Minimum sample volume of 100 µL
• Sample flow rate up to 25 μL/minute
• High-resolution monochrome camera
• Compatible with aqueous solvents for analysis in native buffers
• Ease of use with disposable flow cells and autofocus technology

The ALH for FlowCam™ Automated Liquid Handling system integrates with FlowCam 8000 series instruments, FlowCam LO, and FlowCam Cyano to automate sample handling and FlowCam operation.

ALH for FlowCam minimizes the risk of human error and improves measurement repeatability, ensures safer lab operation, and increases productivity.

• Fully unattended flow imaging microscopy for up to 384 samples
• Higher productivity and improved data reproducibility via automation
• A configurable sample deck for flexible sample queuing and preparation
• HEPA-filtered sample enclosure for cleaner sample handling and particle analysis
• Single channel, 1 mL automated dispensing with Disposable, epT.I.P.S.® Motion style tips
• 10-position plate deck layout supports 8-, 24-, 96-, 384- shallow well and deep well micro-well plates